PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia

@inproceedings{Dey2014PD2Paf1DI,
  title={PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia},
  author={Parama Dey and Satyanarayana Rachagani and Arokia Priyanka Vaz and Moorthy P. Ponnusamy and Surinder K Batra},
  booktitle={Oncotarget},
  year={2014}
}
Pancreatic differentiation 2 (PD2), a PAF (RNA Polymerase II Associated Factor) complex subunit, is overexpressed in pancreatic cancer cells and has demonstrated potential oncogenic property. Here, we report that PD2/Paf1 expression was restricted to acinar cells in the normal murine pancreas, but its expression increased in the ductal cells of KrasG12D/Pdx1Cre (KC) mouse model of pancreatic cancer with increasing age, showing highest expression in neoplastic ductal cells of 50 weeks old mice… CONTINUE READING
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