PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice.

  title={PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice.},
  author={Jingying Zhou and A K L Cheung and Zhiwu Tan and Haibo Wang and Wenbo Yu and Yanhua Du and Yuanxi Kang and Xiaofan Lu and Li Liu and Kwok-Yung Yuen and Zhiwei Chen},
  journal={The Journal of clinical investigation},
  volume={123 6},
Viral vector-based vaccines that induce protective CD8+ T cell immunity can prevent or control pathogenic SIV infections, but issues of preexisting immunity and safety have impeded their implementation in HIV-1. Here, we report the development of what we believe to be a novel antigen-targeting DNA vaccine strategy that exploits the binding of programmed death-1 (PD1) to its ligands expressed on dendritic cells (DCs) by fusing soluble PD1 with HIV-1 GAG p24 antigen. As compared with non-DC… CONTINUE READING


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  • A De Luca
  • J Clin Invest
  • 2012
Highly Influential
5 Excerpts

The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells

  • G Nchinda
  • J Clin Invest
  • 2008
Highly Influential
5 Excerpts

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