PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis

@article{Ishizaki2009PD1AA,
  title={PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis},
  author={Yoshito Ishizaki and Naoko Yukaya and Koichi Kusuhara and Ryutaro Kira and Hiroyuki Torisu and Kenji Ihara and Yasunari Sakai and Masafumi Sanefuji and Judy R. Pipo-Deveza and Catherine Lynn Silao and Benilda C. Sanchez and Marissa Barlaan Lukban and Aida M. Salonga and Toshiro Hara},
  journal={Human Genetics},
  year={2009},
  volume={127},
  pages={411-419}
}
Although the exact pathogenesis of subacute sclerosing panencephalitis (SSPE) remains to be determined, our previous data suggested a genetic contribution to the host susceptibility to SSPE. During chronic viral infection, virus-specific cytotoxic T lymphocytes display poor effector functions. Since co-inhibitory molecules are involved in the suppression of T lymphocytes, we investigated whether single nucleotide polymorphisms (SNPs) of genes encoding co-inhibitory molecules contributed to a… 
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