PD-L2 is a second ligand for PD-1 and inhibits T cell activation

@article{Latchman2001PDL2IA,
  title={PD-L2 is a second ligand for PD-1 and inhibits T cell activation},
  author={Yvette Latchman and C Wood and Tatyana Chernova and Divya Chaudhary and Madhuri Borde and Irene Chernova and Yoshiko Iwai and Andrew J. Long and J. Brown and Raquel J. Nunes and Edward A. Greenfield and Karen Bourque and Vassiliki A. Boussiotis and Laura L. Carter and Beatriz M. Carreno and Nelly Malenkovich and Hiroyuki Nishimura and Taku Okazaki and Tasuku Honjo and Arlene H. Sharpe and Gordon J. Freeman},
  journal={Nature Immunology},
  year={2001},
  volume={2},
  pages={261-268}
}
Programmed death 1 (PD-1)–deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory receptor plays an important role in tolerance. We identify here PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4+ T cells. At low antigen concentrations, PD-L2–PD-1 interactions… CONTINUE READING

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References

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PD-1 inhibits B cell receptor-mediated signaling by recruiting SHP-2 to phosphotyrosine

T. Okazaki, H Nishimura, T. Honjo
  • J. Exp. Med. (Submitted,
  • 2001