PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

@article{Bianchini2019PDL1EO,
  title={PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function},
  author={Mariaelvy Bianchini and Johan Duch{\^e}ne and Donato Santovito and Maximilian J. Schloss and Maximilien Evrard and Holger Winkels and Maria Aslani and Sarajo K Mohanta and Michael Horckmans and Xavier Blanchet and Michael Lacy and Philipp von Hundelshausen and Dorothee Atzler and Andreas J R Habenicht and Norbert Gerdes and Jaroslav Pelisek and Lai Guan Ng and Sabine Steffens and Christian Weber and Remco T. A. Megens},
  journal={Science Immunology},
  year={2019},
  volume={4}
}
PD-L1+Ly6Clo monocytes derive from Ly6Chi monocytes in bone marrow and control T cell survival in tertiary lymphoid organs. Nonclassical Monocyte Marker Nonclassical monocytes (NCMs) are a subset of monocytes that act as sentinels in the skin endothelium and lung microvasculature. The origin of NCMs is not well understood, and Bianchini et al. now identify the immune checkpoint molecule PD-L1 as a marker that can track NCMs. Using two-photon microscopy, PD-L1+ NCMs could be tracked within the… Expand
Non-classical monocytes in cardiovascular physiology and disease.
TLDR
This short review will give an insight about the emerging role of nonclassical monocytes in vascular homeostasis, inflammation and protection in the context of cardiovascular disease. Expand
Transcriptomic signature and metabolic programming of bovine classical and nonclassical monocytes indicate distinct functional specializations
TLDR
Gene transcription indicates that pro-inflammatory and antibacterial processes are associated with cM, while ncM appear to be specialized in regulatory/anti-inflammatory functions and tissue repair, as well as antiviral responses and T-cell immunomodulation. Expand
Notch and TLR signaling coordinate monocyte cell fate and inflammation
TLDR
It is shown that Notch2 is a master regulator of Ly6Chi monocyte cell fate and inflammation in response to TLR signaling. Expand
Notch and TLR signaling coordinate monocyte cell fate and inflammation
TLDR
Notch2 is a master regulator of Ly6Chi monocyte cell fate and inflammation in response to TLR signaling. Expand
PD-L1 in Systemic Immunity: Unraveling Its Contribution to PD-1/PD-L1 Blockade Immunotherapy
TLDR
The utility of PD-L1 expression not only in tumor cells but in immune system cells and their influence on the antitumor activity of immune cell subsets is reviewed. Expand
PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients
TLDR
Evaluating the BM expression profile of PD-L1/PD-1 axis across the different stages of the monoclonal gammopathies suggests that SMM patients could be an interesting target for PD- L1/ PD-1 inhibition therapy, in light of their less compromised and more responsive immune-compartment. Expand
Stroke-Induced Modulation of Myeloid-Derived Suppressor Cells (MDSCs) and IL-10-Producing Regulatory Monocytes
TLDR
A new insight into monocytic function post-stroke is provided since a differential regulation of HLA-DR and PD-L1 was found depending on the IL-10 production of monocytes, which can induce immunosuppression within days after stroke. Expand
Functional crosstalk between T cells and monocytes in cancer and atherosclerosis
TLDR
Monocyte diversity, interactions between monocytes and T cells within tumor and plaque microenvironments, how certain therapies have leveraged these interactions, and novel strategies to assay such associations are reviewed. Expand
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia
TLDR
High plasma levels of several inflammatory cytokines and chemokines, including GM‐CSF, IL‐18, CCL2, CXCL10, and osteopontin, finally confirm the importance of monocytes in COVID‐19 immunopathogenesis. Expand
Inherited and Environmental Factors Influence Human Monocyte Heterogeneity
TLDR
The impact of sex, ethnicity, age, sleep, diet, and exercise on monocyte subsets and their function is outlined, highlighting that steady state is not a single physiological condition. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 42 REFERENCES
Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal
TLDR
Ly6Clow monocytes are intravascular housekeepers that orchestrate the necrosis by neutrophils of endothelial cells that signal a local threat sensed via TLR7 followed by the in situ phagocytosis of cellular debris. Expand
Tumor-derived exosomes modulate PD-L1 expression in monocytes
TLDR
Exosome-mediated transfer of noncoding RNAs to monocytes contributes to cancer-related inflammation and concurrent immune escape via PD-L1 expression, and exosomal hY4 as a driver of TLR7 signaling is identified. Expand
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation
TLDR
CX3CR1 deficiency selectively impairs the recruitment of blood Gr1+ monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs. Expand
Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells
TLDR
The functions of PD-L1 expressed by immune cells in the context of CD8+ T cell priming, contraction, and differentiation into memory populations, as well as the role ofPD-L 1 expressed by tumor cells in regulating antitumor CD8- T cell responses are reviewed. Expand
Genomic Characterization of Murine Monocytes Reveals C/EBP&bgr; Transcription Factor Dependence of Ly6C− Cells
TLDR
It is shown that monocyte differentiation occurred through de novo enhancer establishment and activation of pre‐established (poised) enhancers, and it is revealed that while Ly6C+ and Ly 6C− monocytes are homogeneous in steady state,Ly6Cint cells display heterogeneity. Expand
Regulation and Function of the PD-L1 Checkpoint.
TLDR
The roles of the PD-1-PD-L1 axis in cancer is reviewed, focusing on recent findings on the mechanisms that regulate PD-L 1 expression at the transcriptional, posttranscriptional, and protein level, to inform the design of more precise and effective cancer immune checkpoint therapies. Expand
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response1
TLDR
Three subpopulations of mouse blood monocytes can be distinguished by differential expression of Ly-6C, CD43, CD11c, MBR, and CD62L, which differ in maturation stage and capacity to become recruited to inflammatory sites. Expand
The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes
TLDR
It is found that the orphan nuclear receptor NR4A1 functions as a master regulator of the differentiation and survival of 'patrolling' Ly6C− monocytes in bone marrow of Nr4a1−/− mice. Expand
Immune surveillance of the lung by migrating tissue monocytes
TLDR
It is concluded that monocytes participate in steady-state surveillance of the lung, in a way that is complementary to resident macrophage and dendritic cells and DC, without differentiating into macrophages. Expand
CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs.
TLDR
A MDSC population that expands in CLL is identified and the exact mechanisms responsible for such accumulation remain to be elucidated and it will be of interest to test whether antagonizing suppressive functions of CLL MDSCs could represent a mean for enhancing immune responses. Expand
...
1
2
3
4
5
...