PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

@article{Bianchini2019PDL1EO,
  title={PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function},
  author={Mariaelvy Bianchini and Johan Duch{\^e}ne and Donato Santovito and Maximilian J. Schloss and Maximilien Evrard and Holger Winkels and Maria Aslani and Sarajo K. Mohanta and Michael Horckmans and Xavier Blanchet and Michael Lacy and Philipp von Hundelshausen and Dorothee Atzler and Andreas J. R. Habenicht and Norbert Gerdes and Jaroslav Pelisek and Lai Guan Ng and Sabine Steffens and Christian Weber and Remco T. A. Megens},
  journal={Science Immunology},
  year={2019},
  volume={4}
}
PD-L1+Ly6Clo monocytes derive from Ly6Chi monocytes in bone marrow and control T cell survival in tertiary lymphoid organs. Nonclassical Monocyte Marker Nonclassical monocytes (NCMs) are a subset of monocytes that act as sentinels in the skin endothelium and lung microvasculature. The origin of NCMs is not well understood, and Bianchini et al. now identify the immune checkpoint molecule PD-L1 as a marker that can track NCMs. Using two-photon microscopy, PD-L1+ NCMs could be tracked within the… 

Exosomal PD-L1 induces immunosuppressive non-classical monocytes.

  • A. Diaz
  • Biology, Medicine
    Neuro-oncology
  • 2020
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It is shown that Notch2 is a master regulator of Ly6Chi monocyte cell fate and inflammation in response to TLR signaling.

PD-L1 in Systemic Immunity: Unraveling Its Contribution to PD-1/PD-L1 Blockade Immunotherapy

The utility of PD-L1 expression not only in tumor cells but in immune system cells and their influence on the antitumor activity of immune cell subsets is reviewed.

PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients

Evaluating the BM expression profile of PD-L1/PD-1 axis across the different stages of the monoclonal gammopathies suggests that SMM patients could be an interesting target for PD- L1/ PD-1 inhibition therapy, in light of their less compromised and more responsive immune-compartment.

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