PD-L1 expression and CD274 gene alteration in triple-negative breast cancer: implication for prognostic biomarker

@inproceedings{Guo2016PDL1EA,
  title={PD-L1 expression and CD274 gene alteration in triple-negative breast cancer: implication for prognostic biomarker},
  author={Lei Guo and Wenbin Li and Xinxin Zhu and Yun Ling and Tian Bai Qiu and Lin Dong and Yi Hsuan Fang and Hongying Yang and Jianming Ying},
  booktitle={SpringerPlus},
  year={2016}
}
PURPOSE To estimate the therapeutic potential of PD-L1 inhibition in breast cancer, we evaluated the prevalence and significance of PD-L1 protein expression with a validated antibody and CD274 gene alternation in a large cohort of triple negative breast cancer (TNBC) and correlated with clinicopathological data and patients overall survival. METHODS Immunohistochemistry and in situ mRNA hybridization was used to detect PD-L1 protein and mRNA expression in tumor tissues from 183 TNBC patients… CONTINUE READING
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SpringerPlus (2016) 5:805 was associated with poor prognosis in 870 Chinese patients with breast cancer

  • Guo
  • Oncotarget 6(32):33972–33981
  • 2016

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