PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells

Abstract

T cell receptor (TCR) down-modulation after antigen presentation is a fundamental process that regulates TCR signal transduction. Current understanding of this process is that intrinsic TCR/CD28 signal transduction leads to TCR down-modulation. Here, we show that the interaction between programmed cell death 1 ligand 1 (PD-L1) on dendritic cells (DCs) and… (More)
DOI: 10.1002/emmm.201100165

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.