PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia.

@article{McClanahan2015PDL1CB,
  title={PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia.},
  author={Fabienne McClanahan and Bola S. Hanna and Shaun Miller and Andrew Clear and Peter Lichter and John G Gribben and Martina Seiffert},
  journal={Blood},
  year={2015},
  volume={126 2},
  pages={203-11}
}
Blockade of the programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint augments antitumor immunity and induces durable responses in patients with solid cancers, but data on clinical efficacy in leukemias are sparse. Chronic lymphocytic leukemia (CLL) is associated with a tumor-supportive microenvironment and a dysfunctional immune system, as shown by "exhausted" T cells, defective immunologic synapse formation, and immunosuppressive myeloid cells. These defects… CONTINUE READING

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PD - L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia .
Our data demonstrate that early PD - L1 blockade effectively corrects leukemia - induced immune dysfunction and thus prevents CLL development in mice .
Our data demonstrate that early PD - L1 blockade effectively corrects leukemia - induced immune dysfunction and thus prevents CLL development in mice .
PD - L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia .
Chronic lymphocytic leukemia ( CLL ) is associated with a tumor - supportive microenvironment and a dysfunctional immune system , as shown by " exhausted " T cells , defective immunologic synapse formation , and immunosuppressive myeloid cells .
Chronic lymphocytic leukemia ( CLL ) is associated with a tumor - supportive microenvironment and a dysfunctional immune system , as shown by " exhausted " T cells , defective immunologic synapse formation , and immunosuppressive myeloid cells .
Chronic lymphocytic leukemia ( CLL ) is associated with a tumor - supportive microenvironment and a dysfunctional immune system , as shown by " exhausted " T cells , defective immunologic synapse formation , and immunosuppressive myeloid cells .
Chronic lymphocytic leukemia ( CLL ) is associated with a tumor - supportive microenvironment and a dysfunctional immune system , as shown by " exhausted " T cells , defective immunologic synapse formation , and immunosuppressive myeloid cells .
Chronic lymphocytic leukemia ( CLL ) is associated with a tumor - supportive microenvironment and a dysfunctional immune system , as shown by " exhausted " T cells , defective immunologic synapse formation , and immunosuppressive myeloid cells .
Chronic lymphocytic leukemia ( CLL ) is associated with a tumor - supportive microenvironment and a dysfunctional immune system , as shown by " exhausted " T cells , defective immunologic synapse formation , and immunosuppressive myeloid cells .
Chronic lymphocytic leukemia ( CLL ) is associated with a tumor - supportive microenvironment and a dysfunctional immune system , as shown by " exhausted " T cells , defective immunologic synapse formation , and immunosuppressive myeloid cells .
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