PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing

  title={PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing},
  author={Ilseyar Akhmetzyanova and Malgorzata Drabczyk and Charles Preston Neff and Kathrin Gibbert and Kirsten Katrin Dietze and Tanja Werner and Jia Liu and Lieping Chen and Karl S Lang and Brent E. Palmer and Ulf Dittmer and Gennadiy Zelinskyy and Elaine Wherry},
  booktitle={PLoS pathogens},
Cytotoxic CD8+ T Lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. Signaling of the inhibitory receptor PD-1 is an important mechanism for the development of virus-specific CD8+ T cell dysfunction. However, it has recently been shown that during the initial phase of infection virus-specific CD8+ T cells express high levels of PD-1, but are fully competent in producing cytokines and killing virus-infected target cells. To… CONTINUE READING
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