PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.

@article{Chikuma2009PD1mediatedSO,
  title={PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.},
  author={Shunsuke Chikuma and Seigo Terawaki and Tamon Hayashi and Ryusuke Nabeshima and Takao Yoshida and Shiro Shibayama and Taku Okazaki and T. Honjo},
  journal={Journal of immunology},
  year={2009},
  volume={182 11},
  pages={
          6682-9
        }
}
Accumulating evidence suggests that PD-1, an immuno-inhibitory receptor expressed on activated T cells, regulates peripheral T cell tolerance. In particular, PD-1 is involved in the induction and/or maintenance of T cells' intrinsic unresponsiveness to previously encountered Ags, although the mechanism is yet to be determined. We used a simple experimental model to dissect the mechanism for anergy establishment, in which 2C TCR transgenic rag2(-/-) PD-1(+/+) mice were anergized by a single… CONTINUE READING
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