PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

  title={PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis},
  author={Tim Wartewig and Zsuzsanna Kurgyis and Selina Keppler and Konstanze Pechloff and Erik Hameister and Rupert Oellinger and Roman Maresch and Thorsten Buch and Katja Steiger and Christof Winter and Roland Rad and Juergen Ruland},
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells and are frequently characterized by genetic gain-of-function variants in T cell receptor (TCR) signalling molecules. Although these oncogenic alterations are thought to drive TCR pathways to induce chronic proliferation and cell survival programmes, it remains unclear whether T cells contain tumour suppressors that can… CONTINUE READING


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