PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

@article{Baruch2016PD1IC,
  title={PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease},
  author={Kuti Baruch and Aleksandra Deczkowska and Neta Rosenzweig and Afroditi Tsitsou-Kampeli and Alaa Mohammad Sharif and Orit Matcovitch-Natan and Alexander Kertser and Eyal David and Ido Amit and Michal Schwartz},
  journal={Nature Medicine},
  year={2016},
  volume={22},
  pages={135-137}
}
Systemic immune suppression may curtail the ability to mount the protective, cell-mediated immune responses that are needed for brain repair. By using mouse models of Alzheimer's disease (AD), we show that immune checkpoint blockade directed against the programmed death-1 (PD-1) pathway evokes an interferon (IFN)-γ–dependent systemic immune response, which is followed by the recruitment of monocyte-derived macrophages to the brain. When induced in mice with established pathology, this… CONTINUE READING
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