PD-1 blockade potentially enhances adoptive cytotoxic T cell potency in a human acute myeloid leukaemia animal model.

@article{Deng2018PD1BP,
  title={PD-1 blockade potentially enhances adoptive cytotoxic T cell potency in a human acute myeloid leukaemia animal model.},
  author={Rui Deng and Fang-Yi Fan and Hai Feng Yi and Fang Liu and Guang-cui He and Hao-ping Sun and Y. I. Su},
  journal={Hematology},
  year={2018},
  volume={23 10},
  pages={
          740-746
        }
}
OBJECTIVES Acute myeloid leukaemia (AML) is a malignant haematological disease that remains difficult to cure. Cytotoxic T cell (CTL) adoptive infusion therapy may be conducive to tumour remission by boosting physical immunity. Furthermore, programmed death receptor-1 (PD-1) blockade immunotherapy has shown tremendous success in many cancer therapies. METHOD We attempted to combine these two immunotherapy strategies to intervene in AML by generating AML cellspecific cytotoxic T lymphocytes in… CONTINUE READING
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