PD-1 blockade induces responses by inhibiting adaptive immune resistance

  title={PD-1 blockade induces responses by inhibiting adaptive immune resistance},
  author={Paul C. Tumeh and Christina L. Harview and Jennifer Holmes Yearley and Itsushi Peter Shintaku and Emma J. M. Taylor and L{\'i}dia Robert and Bartosz Chmielowski and Marko Spasi{\'c} and Gina Henry and Voicu Ciobanu and Alisha N. West and Manuel Carmona and Christine Kivork and Elizabeth Seja and Grace Cherry and Antonio Guti{\'e}rrez and Tristan R. Grogan and Christine Mateus and Gorana Tomasic and John A. Glaspy and Ryan O. Emerson and Harlan S. Robins and R. H. Pierce and David A. Elashoff and Caroline Robert and Antoni Ribas},
Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by which cancer tissues limit the host immune response is via upregulation of PD-1 ligand (PD-L1) and its ligation to PD-1 on antigen-specific CD8+ T cells (termed adaptive immune resistance). Here we show that pre-existing CD8+ T cells distinctly located at the invasive tumour margin are associated with expression of the… CONTINUE READING
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