PD-1 blockade: A promising immunotherapy for HIV?

  title={PD-1 blockade: A promising immunotherapy for HIV?},
  author={Bernard J C Macatangay and Charles R. Rinaldo},
  volume={5 4},
The progressive loss of effector function in the setting of chronic viral infections has been associated with the upregulation of programmed death 1 (PD-1), a negative regulator of activated T cells. In HIV infection, increased levels of PD-1 expression correlate with CD8(+) T cell exhaustion, which has been shown in vitro to be reversible with PD-1 blockade. Velu and colleagues recently reported the first in vivo study showing enhancement of a virus-specific immune response through PD-1… CONTINUE READING

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