PD-1 and its ligands in tolerance and immunity.

  title={PD-1 and its ligands in tolerance and immunity.},
  author={Mary E. Keir and Manish J Butte and Gordon J Freeman and Arlene H Sharpe},
  journal={Annual review of immunology},
Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. Immune responses to foreign and self-antigens require specific and balanced responses to clear pathogens and tumors and yet maintain tolerance. Induction and maintenance of T cell tolerance requires PD-1, and its ligand PD-L1 on nonhematopoietic cells can limit effector T cell responses and protect tissues from immune… CONTINUE READING
Highly Influential
This paper has highly influenced 98 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
1,334 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 1,334 extracted citations

Similar Papers

Loading similar papers…