PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients.

@article{Shi2011PD1AP,
  title={PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients.},
  author={F Shi and Ming Shi and Zhen Zeng and Rui-Zhao Qi and Zhen-wen Liu and Ji-yuan Zhang and Yongping Yang and P T Tien and Fu-sheng Wang},
  journal={International journal of cancer},
  year={2011},
  volume={128 4},
  pages={887-96}
}
Programmed death 1 (PD-1) and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of cytotoxic CD8(+) T lymphocytes, the main effector cells in hepatocellular carcinoma (HCC) patients, are not well defined. In this study, we characterized circulating and intratumor PD-1/PD-L1 expression and analyzed their association with disease progression in a cohort of hepatitis B virus-infected patients, including 56… CONTINUE READING

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