PD-1/PD-L1 signaling in JIA synovial regulatory T cell function

Abstract

Regulatory T cells (Treg) are key players in the prevention of aberrant immune responses and can be a future therapeutic target in auto-immunity. Tregs can be induced in the periphery by cytokines like TGFb, or in the presence of inhibitory signals provided by antigen presenting cells. The murine programmed death (PD)-1 molecule is known to induce FOXP3… (More)

Topics

Cite this paper

@inproceedings{Roock2011PD1PDL1SI, title={PD-1/PD-L1 signaling in JIA synovial regulatory T cell function}, author={Sytze de Roock and Genoveva C E Keustermans and Chantal L. Duurland and Ellen J M Wehrens and F Heidy van Wijk and Berent Prakken}, year={2011} }