PD-1-PD-L1 pathway impairs T(h)1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guérin.

@article{Sakai2010PD1PDL1PI,
  title={PD-1-PD-L1 pathway impairs T(h)1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Gu{\'e}rin.},
  author={Shunsuke Sakai and I. K. Kawamura and Taku Okazaki and Kohsuke Tsuchiya and Ryousuke Uchiyama and Masao Mitsuyama},
  journal={International immunology},
  year={2010},
  volume={22 12},
  pages={915-25}
}
A major concern still prevails as to the reason why various mycobacteria are able to persist within infected host in which protective immunity is generated. To address this question, we monitored the generation of protective T cells during infection with Mycobacterium bovis bacillus Calmette-Guérin (BCG). CD4(+) T cells obtained 3 weeks after infection conferred protection against Mycobacterium tuberculosis challenge and produced IFN-γ and tumor necrosis factor (TNF)-α upon antigen stimulation… CONTINUE READING

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