PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.

Abstract

LBA100 Background: Somatic mutations have the potential to be recognized as "non-self" immunogenic antigens. Tumors with genetic defects in mismatch repair (MMR) harbor many more mutations than tumors of the same type without such repair defects. We hypothesized that tumors with mismatch repair defects would therefore be particularly susceptible to immune… (More)
DOI: 10.1056/NEJMc1510353#SA1