PD‑L1 and IDO‑1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I.

@article{Ishihara2020PDL1AI,
  title={PD‑L1 and IDO‑1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I.},
  author={Shin Ishihara and Yuichi Yamada and Takeshi Iwasaki and Masato Yoshimoto and Yu Toda and Kenichi Kohashi and Hidetaka Yamamoto and Yoshihiro Matsumoto and Yasuharu Nakashima and Yoshinao Oda},
  journal={Oncology reports},
  year={2020}
}
The prognosis of undifferentiated pleomorphic sarcoma (UPS) is generally unfavorable. Recently, clinical trials such as SARC028 demonstrated the utility of cancer immunotherapy for soft tissue sarcomas. The aim of the present study was to assess the expression of PD‑L1 and IDO‑1 as prognostic factors and therapeutic targets. A total of 52 primary UPS cases were retrieved and two UPS cell lines were utilized for supplementary analysis. Immunohistochemical staining of anti‑PD‑L1 (28‑8), IDO‑1… 
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