PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport.

@article{Palmer2005PCTAIREPK,
  title={PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport.},
  author={K. J. Palmer and Joanne E Konkel and David J Stephens},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 17},
  pages={3839-47}
}
The export of secretory cargo from the endoplasmic reticulum is mediated by the COPII complex. In common with other aspects of intracellular transport, this step is regulated by protein kinase signalling. Recruitment of the COPII complex to the membrane is known to require ATP and to be blocked by the protein kinase inhibitor H-89. The identity of the specific protein kinase or kinases involved remains equivocal. Here we show that the Sec23p subunit of COPII interacts with PCTAIRE protein… CONTINUE READING