PCSK9 inhibition: current concepts and lessons from human genetics.

Abstract

Low-density lipoprotein cholesterol (LDL-C) plays a central role in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Statins are the cornerstone of therapy for the treatment of elevated LDL-C and for the primary and secondary prevention of ASCVD. However, some patients are intolerant of statins or are unable to achieve acceptable lipid… (More)
DOI: 10.1007/s11883-015-0487-8

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