PCR techniques for clonality assays.

  title={PCR techniques for clonality assays.},
  author={Salvador Diaz-Cano and Alfredo Blanes and Hubert J. Wolfe},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  volume={10 1},
Clonal overgrowths represent the hallmark of neoplastic proliferations, and their demonstration has been proved useful clinically for the diagnosis of malignant lymphomas based on the detection of specific and dominant immunoglobulin and/or T-cell receptor gene rearrangements. Nonrandom genetic alterations can also be used to test clonal expansions and the clonal evolution of neoplasms, especially analyzing hypervariable deoxyribonucleic acid (DNA) regions from patients heterozygous for a given… CONTINUE READING


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