• Biology, Medicine
  • Published in
    American journal of human…
    1997
  • DOI:10.1086/514885

PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies.

@article{Bianchi1997PCRQO,
  title={PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies.},
  author={Diana W. Bianchi and John Mark Williams and Lisa M. Sullivan and Frederick W. Hanson and Katherine Wood Klinger and Anthony P. Shuber},
  journal={American journal of human genetics},
  year={1997},
  volume={61 4},
  pages={
          822-9
        }
}
Fetal cells in maternal blood are a noninvasive source of fetal genetic material for prenatal diagnosis. We determined the number of fetal-cell DNA equivalents present in maternal whole-blood samples to deduce whether this number is affected by fetal karyotype. Peripheral blood samples were obtained from 199 women carrying chromosomally normal fetuses and from 31 women with male aneuploid fetuses. Male fetal-cell DNA-equivalent quantitation was determined by PCR amplification of a Y chromosome… CONTINUE READING

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