PCR mediated recombination impacts the analysis of hepatitis B Virus covalently closed circular DNA


The replication of HBV involves the production of covalently closed circular DNA (cccDNA) from the HBV genome through the repair of virion relaxed circular DNA (rcDNA) in the virion. As cccDNA is the transcription template for HBV genomes, it needs to be eliminated from hepatocytes if the eradication of chronic HBV infection is to be achieved. PCR… (More)
DOI: 10.1186/s12977-016-0318-1

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