PCR in laboratory diagnosis of human Borrelia burgdorferi infections.

@article{Schmidt1997PCRIL,
  title={PCR in laboratory diagnosis of human Borrelia burgdorferi infections.},
  author={Bruno L Schmidt},
  journal={Clinical microbiology reviews},
  year={1997},
  volume={10 1},
  pages={185-201}
}
The laboratory diagnosis of Lyme borreliosis, the most prevalent vector-borne disease in the United States and endemic in parts of Europe and Asia, is currently based on serology with known limitations. Direct demonstration of Borrelia burgdorferi by culture may require weeks, while enzyme-linked immunosorbent assays for antigen detection often lack sensitivity. The development of the PCR has offered a new dimension in the diagnosis. Capable of amplifying minute amounts of DNA into billions of… CONTINUE READING

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