PCR analysis of IgH-gene rearrangements in small lymphoid infiltrates microdissected from sections of paraffin-embedded bone marrow biopsy specimens.

@article{Kremer2000PCRAO,
  title={PCR analysis of IgH-gene rearrangements in small lymphoid infiltrates microdissected from sections of paraffin-embedded bone marrow biopsy specimens.},
  author={Markus Kremer and Antonello Domenico Cabras and Falko Fend and Stephan Schulz and Karl Schwarz and Heinz Hoefler and Martin Werner},
  journal={Human pathology},
  year={2000},
  volume={31 7},
  pages={847-53}
}
The differentiation of benign lymphoid infiltrates from nodular infiltrates of B-cell lymphoma is difficult in bone marrow (BM) biopsy specimens taken from patients with non-Hodgkin's lymphoma (NHL). We investigated whether the determination of clonality by polymerase chain reaction (PCR) analysis of the immunoglobulin heavy chain (IgH) genes could be of help for the distinction of benign and malignant lymphoid infiltrates. BM biopsy specimens of 28 patients were studied, comparing PCR of… CONTINUE READING

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