PCR Analysis of Immunoglobulin Heavy Chain (IgH) and TcR-γ Chain Gene Rearrangements in the Diagnosis of Lymphoproliferative Disorders: Results of a Study of 525 Cases

@article{Thriault2000PCRAO,
  title={PCR Analysis of Immunoglobulin Heavy Chain (IgH) and TcR-γ Chain Gene Rearrangements in the Diagnosis of Lymphoproliferative Disorders: Results of a Study of 525 Cases},
  author={Catherine Th{\'e}riault and Sandrine Galoin and S{\'e}verine Valmary and Janick S{\`e}lves and Laurence Lamant and Daniel Roda and Françoise Rigal-Huguet and P. Brousset and Georges Delsol and Talal Al Saati},
  journal={Modern Pathology},
  year={2000},
  volume={13},
  pages={1269-1279}
}
This report summarizes a cumulative 4-year experience in polymerase chain reaction (PCR) analysis of immunoglobin heavy chain (IgH) and TcR-γ chain gene rearrangements in 525 cases of lymphoproliferative disorders. Because the sensitivity of the PCR methodology was found to be tissue dependent, in the study of the presence of clonal cell population in tissues containing a small number of polyclonal lymphocytes, such as skin and gastrointestinal biopsy specimens, we used the multiple–PCR run… CONTINUE READING