PCP site 2: a high affinity MK-801-insensitive phencyclidine binding site.

@article{Rothman1994PCPS2,
  title={PCP site 2: a high affinity MK-801-insensitive phencyclidine binding site.},
  author={Richard B. Rothman},
  journal={Neurotoxicology and teratology},
  year={1994},
  volume={16 4},
  pages={343-53}
}
Phencyclidine (PCP), a psychotomimetic drug with anticonvulsant and neuroprotective properties interacts with several central nervous system (CNS) macromolecules. These include cholinergic receptors, potassium channels, biogenic amine reuptake systems, the N-methyl-D-aspartate (NMDA) excitatory amino acid receptor, and sigma binding sites. The good correlation between the affinity of arylcycloalkylamines for high affinity PCP binding sites and their ED50 values for inhibition of [3H]dopamine… CONTINUE READING

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