PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic-pituitary-adrenal axis?

Abstract

This review focuses on the role of the ovaries in the pathogenesis of the polycystic ovarian syndrome. In particular, the failure of follicular development, hypothalamo-pituitary dysregulation, alterations in adrenal steroid output and derangement of intermediary metabolism are discussed in the context of the ovaries. It is concluded that the central and… (More)

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