PCNA promotes processive DNA end resection by Exo1

@inproceedings{Chen2013PCNAPP,
  title={PCNA promotes processive DNA end resection by Exo1},
  author={Xiao-qing Chen and Sharad C. Paudyal and Re-I Chin and Zhongsheng You},
  booktitle={Nucleic acids research},
  year={2013}
}
Exo1-mediated resection of DNA double-strand break ends generates 3' single-stranded DNA overhangs required for homology-based DNA repair and activation of the ATR-dependent checkpoint. Despite its critical importance in inducing the overall DNA damage response, the mechanisms and regulation of the Exo1 resection pathway remain incompletely understood. Here, we identify the ring-shaped DNA clamp PCNA as a new factor in the Exo1 resection pathway. Using mammalian cells, Xenopus nuclear extracts… CONTINUE READING

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