PCNA connects DNA replication to epigenetic inheritance in yeast

@article{Zhang2000PCNACD,
  title={PCNA connects DNA replication to epigenetic inheritance in yeast},
  author={Z. M. Zhang and Kei-ichi Shibahara and Bruce W. Stillman},
  journal={Nature},
  year={2000},
  volume={408},
  pages={221-225}
}
Formation of a heterochromatin-like structure results in transcriptional silencing at the HM mating-type loci and telomeres in Saccharomyces cerevisiae. Once formed, such epigenetically determined structures are inherited for many mitotic divisions. Here we show that mutations in the proliferating cell nuclear antigen (PCNA), an essential component at the DNA replication fork, reduced repression of genes near a telomere and at the silent mating-type locus, HMR. The pol30-8 mutant displayed… 
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The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae
TLDR
A comprehensive review of a wide array of biochemical, molecular genetic, cell biological, and genomics studies down to the “nuts and bolts” of silent chromatin and the processes that yield transcriptional silencing.
Noncompetitive Counteractions of DNA Polymerase ε and ISW2/yCHRAC for Epigenetic Inheritance of Telomere Position Effect in Saccharomyces cerevisiae
TLDR
It is shown that the epigenetic states of the telomere gene are not stably inherited in cells either bearing a mutation in a catalytic subunit (Pol2) of replicative DNA polymerase ε (Pol ε) or lacking one of the nonessential and histone fold motif-containing subunits of Pol ε, Dpb3 and Dpb4.
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