PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA

@article{Iida2002PCNACF,
  title={PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA},
  author={Tetsuo Iida and Isao Suetake and Shoji Tajima and Hiroshi Morioka and Satoshi Ohta and Chikashi Obuse and Toshiki Tsurimoto},
  journal={Genes to Cells},
  year={2002},
  volume={7}
}
Background: Proliferating cell nuclear antigen (PCNA) is a ring‐shaped protein known as a processivity factor of DNA polymerase δ. In addition to this role, PCNA interacts with a number of other proteins to increase their local concentration at replicated DNA sites. DNA cytosine methyltransferase 1 (Dnmt1), which preserves epigenetic signals by completing the methylation of hemimethylated DNA after DNA replication, has been indicated as one of these PCNA binding proteins by a previous work… Expand
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