PCNA, the Maestro of the Replication Fork

@article{Moldovan2007PCNATM,
  title={PCNA, the Maestro of the Replication Fork},
  author={George-Lucian Moldovan and B. Pfander and S. Jentsch},
  journal={Cell},
  year={2007},
  volume={129},
  pages={665-679}
}
Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and… Expand
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