PCAF modulates PTEN activity.

  title={PCAF modulates PTEN activity.},
  author={Koichi Okumura and Michelle Mendoza and Robert M. Bachoo and Ronald A. Depinho and Webster K Cavenee and Frank B Furnari},
  journal={The Journal of biological chemistry},
  volume={281 36},
The PTEN protein has a single catalytic domain possessing both lipid phosphoinositol and protein phosphatase activities. The lipid phosphoinositol phosphatase activity is essential for PTEN to block the cell cycle in the G1 phase and thereby to suppress tumor formation and progression (Cantley, L. C., and Neel, B. G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4240-4245), although the mechanisms governing PTEN activity under normal and neoplastic growth conditions remain unclear. Here, we report… CONTINUE READING


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