PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma.

@article{Wang2006PCCG,
  title={PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma.},
  author={Wengang Wang and Jun Ichi Hayashi and Ginette Serrero},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 1},
  pages={49-56}
}
PURPOSE We have shown previously that the 88 kDa glycoprotein PC cell-derived growth factor (PCDGF/GP88) is expressed and acts as an autocrine growth factor in human multiple myeloma cells. The present study investigates whether PCDGF/GP88 expression in multiple myeloma cells leads to the development of resistance to dexamethasone, a conventional drug for multiple myeloma patients. EXPERIMENTAL DESIGN PCDGF functions and signaling pathways in dexamethasone-induced apoptosis were studied using… CONTINUE READING
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