PBRM1 suppresses bladder cancer by cyclin B1 induced cell cycle arrest

@inproceedings{Huang2015PBRM1SB,
  title={PBRM1 suppresses bladder cancer by cyclin B1 induced cell cycle arrest},
  author={Li Huang and Yang Peng and Guangzheng Zhong and Weibin Xie and Wen Dong and Bo Hyeun Wang and Xu Chen and P. W. Gu and Wang Wen He and Shaoxu Wu and Tianxin Lin and Jian Huang},
  booktitle={Oncotarget},
  year={2015}
}
Growing evidence indicates that dys-regulation of PBRM1 contributes to tumorigenesis. However, little is known about the biological function of PBRM1 in the development or progression of bladder cancer. In this study, we aimed to elucidate the pathophysiological role of PBRM1 in bladder cancer. We assessed the expression of PBRM1 in 64 bladder cancer tissue samples with matching normal tissues. We explored the biological functions of PBRM1 both in vitro and in vivo. Mutational status of PBRM1… CONTINUE READING

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