PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals.

@article{Bois2010PBPKMO,
  title={PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals.},
  author={Fr{\'e}d{\'e}ric Y. Bois and Masoud Jamei and Harvey J. Clewell},
  journal={Toxicology},
  year={2010},
  volume={278 3},
  pages={256-67}
}
Generic PBPK models, applicable to a large number of substances, coupled to parameter databases and QSAR modules, are now available for predictive modelling of inter-individual variability in the absorption, distribution, metabolism and excretion of environmental chemicals. When needed, Markov chain Monte Carlo methods and multilevel population models can be jointly used for a Bayesian calibration of a PBPK model, to improve our understanding of the determinants of population heterogeneity and… CONTINUE READING