PBB3 imaging in Parkinsonian disorders: Evidence for binding to tau and other proteins.

@article{PerezSoriano2017PBB3II,
  title={PBB3 imaging in Parkinsonian disorders: Evidence for binding to tau and other proteins.},
  author={Alexandra Perez-Soriano and Julieta E. Arena and Katie Dinelle and Qing Robert Miao and Jessamyn Mckenzie and Nicole Neilson and Andreas Puschmann and Paul Schaffer and Hitoshi Shinotoh and Jenna Smith-Forrester and Elham Shahinfard and Nasim Vafai and Daryl J. Wile and Zbigniew K Wszolek and Makoto Higuchi and Vesna Sossi and A. Jon Stoessl},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2017},
  volume={32 7},
  pages={1016-1024}
}
BACKGROUND AND OBJECTIVES To study selective regional binding for tau pathology in vivo, using PET with [11 C]PBB3 in PSP patients, and other conditions not typically associated with tauopathy. METHODS Dynamic PET scans were obtained for 70 minutes after the bolus injection of [11 C]PBB3 in 5 PSP subjects, 1 subject with DCTN1 mutation and PSP phenotype, 3 asymptomatic SNCA duplication carriers, 1 MSA subject, and 6 healthy controls of similar age. Tissue reference Logan analysis was applied… CONTINUE READING
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