PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.

@article{Bussey2010PB2R2,
  title={PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.},
  author={Kendra A Bussey and Tatiana L. Bousse and Emily A. Desmet and Baek ki Kim and Toru Takimoto},
  journal={Journal of virology},
  year={2010},
  volume={84 9},
  pages={4395-406}
}
The direct infection of humans with highly pathogenic avian H5N1 influenza viruses has suggested viral mutation as one mechanism for the emergence of novel human influenza A viruses. Although the polymerase complex is known to be a key component in host adaptation, mutations that enhance the polymerase activity of avian viruses in mammalian hosts are not fully characterized. The genomic comparison of influenza A virus isolates has identified highly conserved residues in influenza proteins that… CONTINUE READING

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