PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice.

@article{Cheng2014PB2E627KAP,
  title={PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice.},
  author={Kaihui Cheng and Zhijun Yu and Hongliang Chai and Weiyang Sun and Yue Xin and Qianyi Zhang and Jingjing Huang and Kun Zhang and Xue Li and Songtao Yang and Tiecheng Wang and Xuexing Zheng and Hualei Wang and Chuan Qin and Jun Qian and Hualan Chen and Yuping Hua and Yuwei Gao and X D Xia},
  journal={Virology},
  year={2014},
  volume={468-470},
  pages={
          207-213
        }
}
H6N1 avian influenza viruses (AIVs) may pose a potential human risk as suggested by the first documented naturally-acquired human H6N1 virus infection in 2013. Here, we set out to elucidate viral determinants critical to the pathogenesis of this virus using a mouse model. We found that the recombinant H6N1 viruses possessing both the PA-T97I and PB2-E627K substitutions displayed the greatest enhancement of replication in vitro and in vivo. Polymerase complexes possessing either PB2-E627K, PA… CONTINUE READING

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