PAX6 suppresses the invasiveness of glioblastoma cells and the expression of the matrix metalloproteinase-2 gene.

@article{Mayes2006PAX6ST,
  title={PAX6 suppresses the invasiveness of glioblastoma cells and the expression of the matrix metalloproteinase-2 gene.},
  author={Debra A. Mayes and Yuanjie Hu and Yue Teng and Eric Siegel and Xiaosong Wu and Kishori Moni Panda and Fang Tan and W. K. Alfred Yung and Yi-hong Zhou},
  journal={Cancer research},
  year={2006},
  volume={66 20},
  pages={
          9809-17
        }
}
Glioblastoma multiforme (GBM) is the most invasive brain tumor. We have previously reported that the transcription factor PAX6 suppresses the tumorigenecity of GBM cells. By an in vitro Matrigel invasion assay on two GBM cell lines stably transfected with wild-type and/or two mutant forms of PAX6, this study displays the first evidence that PAX6 inhibits the invasiveness of GBM cells and that the DNA-binding domain of PAX6 is required for this function. Using real-time quantitative reverse… CONTINUE READING

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