PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation.

Abstract

Tumors of the exocrine pancreas are a major cause of cancer death and have among the poorest prognosis of any malignancy. Following the "cancer stem cell hypothesis," where tumors are believed to originate in tissue specific stem cells, we screened primary ductal pancreatic carcinomas and cell lines for the expression of possible stem cell factors. We find… (More)

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