PAX6 in sensory development.

  title={PAX6 in sensory development.},
  author={Veronica van Heyningen and Kathleen A. Williamson},
  journal={Human molecular genetics},
  volume={11 10},
PAX6 function was first identified through aniridia-associated null mutations. Since then, this transcription factor, with a paired domain and a homeodomain, has become a paradigm, illustrating functional conservation in developmental pathways. The Small eye mouse and Drosophila eyeless have served as major model systems in defining the multistage roles for Pax6 in eye and olfactory system development throughout evolution. The overt phenotypic consequences of heterozygous human and mouse Pax6… CONTINUE READING