PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis.

@article{Zeng2009PAX3FKHRSH,
  title={PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis.},
  author={Fu-Yue Zeng and Jimmy Cui and Lingling Liu and Taosheng Chen},
  journal={Cancer letters},
  year={2009},
  volume={284 2},
  pages={157-64}
}
Patients with alveolar rhabdomyosarcoma (ARMS) have poorer response to conventional chemotherapy and lower survival rates than those with embryonal RMS (ERMS). By high-throughput screening, we identified camptothecin as an ARMS-selective inhibitor. Camptothecin more efficiently inhibited proliferation and induced apoptosis in Rh30 (ARMS) than RD (ERMS) cells. Ectopic expression of the PAX3-FKHR (PF) fusion protein in RD cells significantly increased sensitivity, whereas siRNA knockdown of PF… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS