PATHOGENESIS OF CROHN'S DISEASE: MULTIFOCAL GASTROINTESTINAL INFARCTION

@article{Wakefield1989PATHOGENESISOC,
  title={PATHOGENESIS OF CROHN'S DISEASE: MULTIFOCAL GASTROINTESTINAL INFARCTION},
  author={A. Wakefield and A. Dhillon and P. Rowles and A. Sawyerr and R. Pittilo and A. Lewis and R. Pounder},
  journal={The Lancet},
  year={1989},
  volume={334},
  pages={1057-1062}
}
In a prospective study, specimens of resected small and large intestine from fifteen patients with Crohn's disease were prepared by heparin-saline vascular perfusion, followed by either resin casting of the mesenteric vascular supply and tissue maceration or glutaraldehyde perfusion-fixation, resin casting, and tissue clearance. The specimens were examined by macrophotography, histopathology, and either scanning or transmission electronmicroscopy. A pathogenetic sequence of events in Crohn's… Expand
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