PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics.

@article{Marwaha2007PASSpredictedDS,
  title={PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics.},
  author={Alka Marwaha and Rajesh Kumar Goel and Mohinder Pal Mahajan},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 18},
  pages={5251-5}
}
Out of 400 virtually designed imidazoline N-oxides, five cyclic nitrones were selected on the basis of PASS prediction as potent nootropics and were evaluated for their biological activities in albino mice. The selected N-alkyl and aryl-substituted nitrones were found to be excellent nootropics. A series of lead compounds acting as cognition enhancers have been provided, which can be further exploited in search of such New Chemical Entities (NCEs).