PAS Kinase as a Nutrient Sensor in Neuroblastoma and Hypothalamic Cells Required for the Normal Expression and Activity of Other Cellular Nutrient and Energy Sensors

@article{HurtadoCarneiro2013PASKA,
  title={PAS Kinase as a Nutrient Sensor in Neuroblastoma and Hypothalamic Cells Required for the Normal Expression and Activity of Other Cellular Nutrient and Energy Sensors},
  author={Ver{\'o}nica Hurtado-Carneiro and Isabel M. Roncero and Enrique Bl{\'a}zquez and E. Fernandez Alvarez and Carmen Sanz},
  journal={Molecular Neurobiology},
  year={2013},
  volume={48},
  pages={904-920}
}
PAS kinase (PASK) is a nutrient sensor that is highly conserved throughout evolution. PASK-deficient mice reveal a metabolic phenotype similar to that described in S6 kinase-1 S6K1-deficient mice that are protected against obesity. Hypothalamic metabolic sensors, such as AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR), play an important role in feeding behavior, the homeostasis of body weight, and energy balance. These sensors respond to changes in nutrient… CONTINUE READING
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