PARTITION COEFFICIENTS OF SOME AROMATIC ALCOHOLS IN AN n‐HEPTANE/WATER SYSTEM AND THEIR RELATIONSHIP TO MINIMUM INHIBITORY CONCENTRATION AGAINST PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS

@article{Wilson1981PARTITIONCO,
  title={PARTITION COEFFICIENTS OF SOME AROMATIC ALCOHOLS IN AN n‐HEPTANE/WATER SYSTEM AND THEIR RELATIONSHIP TO MINIMUM INHIBITORY CONCENTRATION AGAINST PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS},
  author={J. Wilson and J. Lyall and R. Mcbride and J. B. Murray and G. Smith},
  journal={Journal of Clinical Pharmacy and Therapeutics},
  year={1981},
  volume={6}
}
The partition coefficients of the homologous series of aromatic alcohols were determined in an n‐heptane/water system. The minimum inhibitory concentrations of benzyl alcohol, 2‐phenylethanol, 3‐phenylpropanol, 4‐phenylbutanol and 5‐phenylpentanol were elucidated against Pseudomonas aeruginosa and Staphylococcus aureus. 
Antibacterial activity of phenolic compounds and aromatic alcohols.
TLDR
Since it was demonstrated that the lethal effect of two aromatic alcohols stops when protein synthesis is inhibited, it is likely that both possess specific mechanisms of action. Expand
Aromatic alcohols and their effect on Gram-negative bacteria, cocci and mycobacteria.
TLDR
It is reported that PEA was only slightly less inhibitory to Staphylococcus aureus than Escherichia coli, and that the MIC for Pseudomonas aeruginosa was 0.46% (4600 mg/L). Expand
Inhibition aspects of the bioconversion of l-phenylalanine to 2-phenylethanol by Saccharomyces cerevisiae
TLDR
Higher specific oxygen uptake ratesqO2 were found in the presence of the bioconversion at oxidative growth than the maximal respiratory capacity qO2max found in continuous cultures without bioconversions. Expand
Extractive Bioconversion of 2‐Phenylethanol from l‐Phenylalanine by Saccharomycescerevisiae
TLDR
The production rates were limited by the intrinsic oxidative capacity of S. cerevisiae, and the high viscosity of the two‐phase system lowered the kla, and therefore also the productivity, so if a specific ISPR technique is planned, it consequently has to be remembered that the productivity of this bioconversion process is also quickly limited byThe kla of the fermenter at high cell densities. Expand
Biosynthesis of 2-phenylethanol using tobacco waste as feedstock
Abstract 2-Phenylethanol (2-PE) is an aromatic alcohol with a rose-like odour, which is widely used in the food, drink and cosmetic industry. It also present in cigarette aromas. As a uniqueExpand
Interactions Between Peptide and Preservatives: Effects on Peptide Self-Interactions and Antimicrobial Efficiency In Aqueous Multi-Dose Formulations
TLDR
Peptide-preservative interactions not only affect peptide self-interactions, but also antimicrobial efficiency of the preservatives and are thus of significant relevance. Expand
4 Final Report on the Safety Assessment of Phenethyl Alcohol
  • 1990
Phenethyl Alcohol (PEA) is an aromatic alcohol that is used as a fragrance and an antimicrobial preservative in cosmetic formulations. PEA is metabolized to phenyl-acetic acid in mammals. In humans,Expand
Purification and identification of antibacterial phenolics from Tripodanthus acutifolius leaves
Aims:  To perform an activity‐guided purification, identification and quantification of antibacterial compounds from Tripodanthus acutifolius infusion. To validate the antibacterial activity ofExpand
De-novo synthesis of 2-phenylethanol by Enterobacter sp. CGMCC 5087
TLDR
The phenylpyruvate pathway and the substrate specificity of 2-keto-acid decarboxylase towards phenyl pyruVate were found in E. sp. Expand
Improving flavor metabolism of Saccharomyces cerevisiae by mixed culture with Wickerhamomyces anomalus for Chinese Baijiu making.
TLDR
New insights into yeasts interactions in Baijiu fermentation and the effect of some primary metabolites on the end flavor and BaijiU quality are provided. Expand

References

SHOWING 1-7 OF 7 REFERENCES
Correlation of partition coefficients in n‐heptane‐aqueous systems with buccal absorption data for a series of amines and acids
TLDR
Those amines and acids having similar partition coefficients, when equally unionized, were absorbed to the same extent in the buccal test over the pH range 4 to 9. Expand
The selective antibacterial action of phenylethyl alcohol.
  • B. D. Lilley, J. H. Brewer
  • Chemistry, Medicine
  • Journal of the American Pharmaceutical Association. American Pharmaceutical Association
  • 1953
TLDR
It is reported that phenylethyl alcohol in relatively low concentrations (1:400) exerts an effective inhibitory action on Gram‐negative bacteria and may thus be used for differential inhibition. Expand
Effect of 3-phenylpropan-1-ol, 2-phenylethanol, and benzyl alcohol on Pseudomonas aeruginosa.
TLDR
3-phenylpropan-1-ol may be a suitable preservative for oral suspensions and mixtures and enhance the bactericidal action of benzalkonium chloride against P. aeruginosa in the same ranking order. Expand
The uptake by Escherichia coli and growth inhibitory properties of benzyl alcohol and phenethyl alcohol MILDRED LANG
  • R. M. Rye
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1972
TLDR
The effects of benzyl alcohol and phenethyl alcohol on the rate of mass increase in cultures of E. coli were studied by absorbance measurements and the inhibition of growth was shown to be reversible and to result from a uniform inhibition of the individual cells. Expand
Linear relationships between lipophilic character and biological activity of drugs.
0 Chloroacetaldehyde, a probable metabolite of 2-chlorc- ethanol (ethylene chlorohydrin), was studied in a number of itz oiuo animal systems, in in oitro hemolysis tests, and in tissue cultures toExpand
Effects of phenethyl alcohol on Bacillus and Streptococcus
The activity of phenethyl alcohol (PEA) on Bacillus cereus, B. megaterium, and Streptococcus faecalis was studied by electron microscopy of thin sections and by the assay of intracellular K+ leakage.Expand